Lipophilicity and Biomimetic Properties Supporting Drug Discovery
Lipophilicity
Course description
Introductory free short description of the drug discovery process.
How do medicinal chemists design the required properties into a candidate molecule?
How to measure octanol/water partition coefficients?
Look for more detailed courses on
Lipophilicity
Biomimetic properties
How to measure protein binding?
How to measure phospholipid binding?
How lipophilicity and biomimetic binding depends on the charge?
How to apply the measured lipophilicity and protein binding data to estimate in vivo drug distribution?
Links to other courses:
Lipophilicity course
Biomimetic properties course
Abraham solvation equation course
pH dependence of lipophilicity course
Solubility in early drug discovery course
Permeability in early drug discovery course
In vivo models course
Klara Valko
Intro slides wise screen shortened
FREE PREVIEWVideo 1.1 Screening cascade
FREE PREVIEWVideo 2.1 Property spaces
FREE PREVIEWVideo 3.1 Distribution
FREE PREVIEWVideo 5.1 Octanol water partition
FREE PREVIEWVideo 5.2 Chromatographic Hydrophobicity
FREE PREVIEWVideo 5.4 Biomimetic HPLC
FREE PREVIEWTest your level of knowledge
FREE PREVIEWIf you have any question from the tutor please use the discussion, so other students can also learn from your questions and from the answer.
This course is excelent. The subject is described in a simple and clear way. I suggest it to all medicinal chemists.
This course is excelent. The subject is described in a simple and clear way. I suggest it to all medicinal chemists.
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